21 August 2015

Cannabinoid and Endocannabinoid Research Timeline


Almost all early research was devoted to clarification of cannabinoid chemistry34104105, and pharmacology was mainly done using synthetic compounds5. Following the isolation and structure elucidation of the plant cannabinoids, particularly of cannabidiol106 and of Δ9-tetrahydrocannabinol (Δ9-THC)6, pharmacological and physiological work was initiated8915. The identification of cannabinoid receptors242931, of endogenous cannabinoids3032107 and of receptor antagonists5066 made possible extensive pharmacological and neurobiological research leading to cloning of the anandamide-degrading enzyme fatty acid amide hydrolase (FAAH)108, the discovery of retrograde signaling by 2-arachidonoyl glycerol (2-AG)45, the discovery of allosteric sites on cannabinoid receptor 1 (CB1)33, the discovery that endocannabinoids bind to receptors other than CB1 and CB2 (Refs 109, 110, 111), the discovery and evaluation of endocannabinoid-like molecules in the brain9596 and the discovery and function of inhibitors of the endocannabinoid-degrading enzymes112113. Cell biology114and neuroscience115116 investigations were also carried out, and clinical trials were initiated101117118. Cloning of DAG lipase was also reported119.

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